MEMO THERAPEUTICS AG IDENTIFIES POTENT SARS-COV-2-NEUTRALIZING ANTIBODIES FROM THE BLOOD OF RECOVERED COVID-19 PATIENTS
Schlieren, Switzerland – 4 June 2020 – Memo Therapeutics AG (“MTx”), an innovator in the field of antibody discovery and immune repertoire analysis, today announces that it has identified several SARS-CoV-2-specific virus-neutralizing antibodies with the potential for development as a COVID-19 immunotherapy.
- MTx’s DROPZYLLA® platform isolated ultra-rare and highly potent virus-neutralizing antibodies from COVID-19 patients within six weeks
- SARS-CoV-2-specific antibodies to be developed as a COVID-19 immunotherapy
Since March, MTx has selected the most promising donors from hundreds of Swiss COVID-19 patients. The selection criteria identified patients who had demonstrated a clinical course of COVID-19 indicative of a particularly potent antibody response.
Blood samples were collected from the clinically selected donors and used with MTx’s microfluidic DROPZYLLA® discovery platform to identify SARS-CoV-2-neutralizing antibodies. DROPZYLLA® enables the generation of complete recombinant human antibody repertoires, preserving all specificities present in each of the patient’s B cells.
By processing more than 2 million memory B cells from the COVID-19 donors, MTx was able to identify ultra-rare antibodies with superior virus-neutralizing activity within just six weeks of first patient enrollment. The most potent of these antibodies will now undergo clinical development as a passive immunotherapy for COVID-19, with a clinical proof-of-concept anticipated for Q4 this year.