Donald L. Price Memorial Lecture on Cryo-EM Structures of Disease Filaments from Human Brains to be presented at AD/PD 2024
Neurimmune announced today that a Donald L. Price Memorial Lecture will be held at the 18th International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders, AD/PD 2024, in Lisbon, Portugal and virtually from March 5 to March 9, 2024. Professor Michel Goedert, Program Leader at the Medical Research Council Laboratory of Molecular Biology in Cambridge UK will be presenting the lecture entitled “Cryo-EM structures of disease filaments from human brains” on Wednesday, March 6th at 8:00 a.m. local time.
Donald L. Price (1935-2023) was an extraordinary leader in the fields of clinical and experimental neuropathology and a professor at the John Hopkins School of Medicine. His pioneering research efforts led to discoveries related to cholinergic dysfunction in AD, axonal transport, comparative neuropathology and aging in nonhuman primates and the development of mouse models of neurodegenerative diseases. Don Price served as President of the American Association of Neuropathologists in 1989 and President of the Society for Neuroscience in 2000.1 In recognition, Neurimmune is supporting a series of Donald L. Price Memorial Lectures through educational grants with the first lecture to be held by Professor Michel Goedert at AD/PD 2024.
Alzheimer’s disease is characterized by the presence of two different filamentous amyloid inclusions in brain: abundant extracellular plaques of Aβ and intraneuronal neurofibrillary tangles of tau. Michel Goedert’s work at the Medical Research Council Laboratory of Molecular Biology in Cambridge UK is focused on electron cryo-microscopy to determine high-resolution structures of such filaments. He recently discovered structures of amyloid-β 42 amyloid filaments from human brains and his findings may contribute to future development of small molecule inhibitors of assembly and improved imaging agents for Alzheimer’s disease.2
1 Sisodia S & Wong PC. Donald Lowell Price, M.D. In memoriam. Molecular Neurodegeneration 2023,18:88.
2 Yang Y et al., Cryo-EM structures of amyloid-β 42 filaments from human brain, Science 2022, 375(6577):167.